How do regular supplements differ from MAOI extracts?

Nowadays, more and more people are interested in supplementing nutrients and supporting mental health through dietary supplements. Among the less-known but highly effective substances are MAOIs (monoamine oxidase inhibitors). How do MAOI extracts differ from regular supplements, and what are their effects on the body and brain?

What are MAOIs?

MAOIs are substances that block the enzyme monoamine oxidase. This enzyme in the body breaks down neurotransmitters such as serotonin, dopamine, and norepinephrine, which affect mood, energy, and motivation.

• MAOI extracts are usually obtained from plants and herbs traditionally used in medicine, such as Banisteriopsis caapi, Passiflora incarnata, or certain Asian herbs.

• Their effect is targeted and potent, as they directly influence neurotransmitter levels in the brain.

Unlike regular supplements, MAOI extracts have a specific psychoactive effect that can influence mood, cognitive function, and mental balance.

Regular supplements vs. MAOI extracts

Let’s look at the main differences between MAOI extracts and classic dietary supplements.

1. Mechanism of action

Regular dietary supplements

1. Contain vitamins, minerals, herbs, or amino acids.
2. Their effect is often general, e.g., supporting immunity, energy, recovery, or sleep.
3. They act more preventively and in the long term.

MAOI extracts

• Specifically block the monoamine oxidase enzyme and thus increase neurotransmitter levels.
• The effect is usually faster and more intense, especially on mood and mental energy.
• They may have psychoactive effects, so they should be used with caution.

2. Dosage and safety

Regular supplements

• Usually safe at standard dosages.
• Mild side effects are rare.

MAOI extracts

• Require precise dosing, as too high a dose can cause unwanted effects such as high blood pressure, nausea, or anxiety.
• Interactions with certain medications (e.g., antidepressants) or foods (tyramines) can be dangerous.

3. Target effects

Regular supplements

• Support energy, sleep, immunity, digestion, joints.
• Their effect is generally subtle and long-term.

MAOI extracts

• Increase levels of serotonin, dopamine, and norepinephrine.
• May influence mood, motivation, creativity, and sensory perception.
• Used purposefully, often for mental well-being or traditional rituals.

4. Form and availability

Regular supplements

• Tablets, capsules, powders, drinks, teas.
• Freely available in pharmacies and stores.

MAOI extracts

• Extracts, tinctures, concentrated capsules.
• Often require special preparation or dosing and are not as commonly available.

Main differences

Possible side effects of MAOI extracts

• Mild nausea or stomach discomfort
• Increased blood pressure if used improperly
• Psychological effects such as nervousness, anxiety, or insomnia
• Interactions with medications (especially antidepressants)

Recommendation: Using MAOIs requires caution. Combining them with certain drugs or foods can be dangerous. Always start with a low dose and consult a specialist before use.

Conclusion

The difference between regular dietary supplements and MAOI extracts is significant. While regular supplements act more preventively and over the long term, MAOI extracts have a targeted effect on neurotransmitters and can quickly influence mood, energy, and mental balance.