Kanna, or Sceletium tortuosum in Latin, is a plant from South Africa known for its positive effects on the body and mind. Although it is often used as a dietary supplement or herb, using kanna is not entirely without risks. We will reveal the side effects of kanna and recommendations for safe use.

Most common side effects
Although kanna is considered relatively safe, some common side effects may occur, especially at higher doses:
- Headaches – occasional headaches may appear in more sensitive individuals.
- Dry mouth and dehydration – typical for the alkaloids found in kanna, especially mesembrine.
- Mood changes – nervousness, irritability, or short-term euphoria.
- Nausea and stomach issues – some people may experience mild digestive problems.
- Dizziness and drowsiness – may occur at higher doses or when combined with alcohol.
Side effects usually appear with excessive use or inappropriate administration.
Risks when combined with medications
Kanna affects serotonin levels in the brain, so caution is important when combining it with certain medications. The most risky include:
- Antidepressants (SSRI, MAOI) – combining with kanna may increase the risk of serotonin syndrome.
- Blood pressure medications – use kanna with caution, as it may affect blood pressure and heart rate.
- Psychotropic substances – kanna can enhance the effects of other stimulants or sedatives.
If you are taking any medications, it is always advisable to consult your doctor before using kanna to minimize health risks.
Risks of excessive use
Regular or high doses of kanna may cause:
- Tolerance – the body gradually adapts, and effects decrease.
- Psychological dependence – although kanna is not physically addictive, some users may become dependent on the mood-enhancing effect.
- Sleep disturbances – excessive use may affect sleep quality and cause insomnia.
- Unpredictable psychological reactions – especially in individuals predisposed to anxiety or depression.
Methods of use and risk factors
Kanna can be used in various ways – snorting, capsules, tea, or chewing. Each method has its advantages and potential risks:
- Snorting – fast onset of effects, but may irritate the nasal mucosa.
- Capsules – convenient and precise dosing, milder effects.
- Tea – slower onset of effects, suitable for relaxation.
- Chewing dried plant – traditional method, natural effect, but less precise dosing.
How to minimize risks
Several principles apply for safe use of kanna:
- Start with a small dose and gradually increase according to your body’s reactions.
- Do not exceed the recommended dose or duration of use.
- Monitor your body – if unusual symptoms appear, stop using it.
- Avoid combining with alcohol or medications that affect the brain or heart.
If you want to know how to dose kanna correctly and prevent side effects, we recommend reading the article: How to Dose Kanna.
Conclusion
Kanna is a plant with proven positive effects on mood, stress, and anxiety. Nevertheless, side effects and risks should not be underestimated, especially with excessive use or when combined with medications. Information about risks, safe dosing, and methods of use helps minimize unpleasant effects and ensures a safe and pleasant experience.