Many things are said about fisetin, such as that it can extend life, protect the brain, and help the body get rid of old, damaged cells. It sounds great, but like with any active substance, it’s important to know what to watch out for. If you’re considering fisetin, let’s first take a look at a few important things you should know.

What is fisetin?
Fisetin is a flavonoid that naturally occurs in certain foods, especially in strawberries, apples, grapes, and even onions. What are flavonoids? Flavonoids are compounds that give fruit and vegetables their bright color and have strong antioxidant effects.
If you want to learn more about fisetin, especially in a positive sense, we recommend reading our previous article: What is Fisetin and what are its effects?
What effects does this flavonoid offer?
In the previous article, you’ll find a more detailed look at the effects of fisetin. Now let’s summarize them so we know why we’re even talking about fisetin.
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Antioxidant effects: Fisetin helps scavenge free radicals and protects the body from oxidative stress, meaning it could potentially slow aging and protect cells.
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Brain health support: Fisetin also offers neuroprotective benefits by maintaining brain cell health and improving cognitive functions.
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Anti-inflammatory effects: Fisetin may help alleviate chronic inflammation in the body, which is important for preventing various diseases, including heart disease and cancer.
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Skin health improvement: Thanks to its antioxidant properties, fisetin can help protect the skin from UV damage and improve its appearance.
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Immune system support: Fisetin may support the body's immune response and help it defend against infections.
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Heart health improvement: This flavonoid plays a good role in the cardiovascular system by taking care of blood vessels and ensuring good circulation.
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Metabolism support: Fisetin can help improve metabolism and support healthy blood sugar levels, which is useful for diabetes prevention.
Even though you can see for yourself that fisetin promises a range of benefits, as with any active substance, it’s important to keep in mind a few key things to watch out for.
What to watch out for?
Let’s talk about what to focus on before taking fisetin.
1. Correct dosage is crucial
Even though fisetin is a flavonoid offering many health benefits, it’s still important to not exceed recommended doses. This generally applies to everything. Most studies focus on doses of around 100 mg to 500 mg per day, but higher doses may cause side effects such as stomach issues, headaches, etc.
2. Combining with other supplements or medications
If you are taking other dietary supplements or medications, fisetin can affect their effects. For example, it may enhance the effectiveness of certain anti-inflammatory drugs or affect blood sugar levels. This is especially important if you suffer from diabetes or are taking blood sugar-lowering medication.
3. Possible drug interactions
Fisetin may have interactions with medications, especially those that affect blood clotting. If you are taking blood thinners or have cardiovascular health issues, consult your doctor before starting fisetin.
4. Don’t forget balance
As with all supplements, they work best in combination with a balanced diet and a healthy lifestyle. Fisetin is no exception in this regard. Remember that no supplement can replace a varied and balanced diet, physical activity, or other key elements of a healthy life.
5. Not for everyone
Although fisetin may be beneficial for many people, it may not be suitable for everyone. Remember that we are all different and not everyone may have the same positive or negative reactions to fisetin. Which brings us to the question:
Who should avoid fisetin?
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Pregnant and breastfeeding women: We’re not saying it’s always dangerous to take fisetin during pregnancy, but there’s a big HOWEVER. Due to the lack of research on the safety of fisetin during pregnancy and breastfeeding, these women should always consult a doctor before using fisetin.
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People allergic to flavonoids: If you have a known allergy to flavonoids or related compounds, you should avoid fisetin.
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People taking blood thinners: Fisetin may affect blood clotting, so people taking anticoagulants (blood thinners) should consult a doctor before using fisetin.
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People with stomach issues: Fisetin may have an irritating effect on some individuals, so people with sensitive stomachs or gastrointestinal problems should avoid using fisetin or consult an expert first.
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People with kidney or liver diseases: Since fisetin is metabolized in the liver, people with liver or kidney function disorders should avoid excessive fisetin intake and consult a doctor.
Tip for an article: Who really should not take Turmeric
Summary
When taking fisetin, it’s important to be aware of all potential risks and interactions with other medications. If you have any doubts, always consult your doctor or a nutrition specialist. But keep in mind that fisetin can be a powerful health support tool, but only if used correctly.